Alkyl fluorides
Sigma Aldrich Heptafluorobutyric acid
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich Pentafluoropropionic anhydride
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich Perfluorooctanoic Acid
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich Heptafluorobutyric anhydride
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
eMolecules 307-24-4 | Perfluorohexanoic acid | Combi-Blocks, Inc. | MFCD00198040 | 314.054 | C6HF11O2 | 98.000 | OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F | 25g | 586077635
Perfluorohexanoic acid | Combi-Blocks, Inc. | 307-24-4 | MFCD00198040 | 314.054 | C6HF11O2 | 98.000 | OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F | 25g | 586077635
Medchemexpress LLC Ensartinib | 1365267-27-1 | 98.10% | 547.41 | 10 MM * 1 ML
X-376 is a potent and highly specific ALK tyrosine kinase inhibitor (TKI) with an IC50 of 0.61 nM. It is also a less potent inhibitor of MET (IC50=0.69 nM), exhibiting potent anti-tumor activity. This compound shows substantial bioavailability and moderate half-lives in vivo. Intended for research use only, animal studies indicate it is well-tolerated at effective doses without significant toxicity up to 50 mg/kg in SD rats.
- Potent ALK inhibitor (IC50: 0.61 nM)
- Inhibits MET (IC50: 0.69 nM)
- Potent in H3122, H2228, and SUDHL-1 cancer cells
- Soluble in DMSO (100 mg/mL)
- Well-tolerated in vivo with anti-tumor activity
- Stock solution storage: -80°C for 2 years, -20°C for 1 year
Medchemexpress LLC Perfluorohexanoic acid | 307-24-4 | 99.9% | 314.05 | 5 G
Perfluorohexanoic acid (Undecafluorocaproic acid) is a biological molecule. It is for research use only and not sold to patients. It is used as a laboratory chemical and in the manufacture of substances.
- Target: Biochemical assay reagents
- Stable under recommended storage conditions
- Recommended storage temperature: Store at room temperature for 3 years, in solvent at -80°C for 2 years or -20°C for 1 year
- Product is for research use only and for experienced personnel
Medchemexpress LLC Perfluorododecanoic acid | 307-55-1 | MFCD00198081 | 95.0% | 614.10 g·mol⁻¹ | C12HF23O2 | 10 MG
Perfluorododecanoic acid is a perfluoroalkyl carboxylic acid used as a research reagent to investigate PFAS-driven biological effects such as cytotoxicity, increased reactive oxygen species, and altered mitochondrial membrane potential. It is provided as a high-purity solid for laboratory studies.
eMolecules 375-72-4 | PERFLUOROBUTANESULFONYL FLUORIDE | AstaTech | MFCD00007422 | 302.090 | C4F10O2S | 95.000 | FC(F)(F)C(F)(F)C(F)(F)C(F)(F)S(F)(=O)=O | 50g | 392631970
PERFLUOROBUTANESULFONYL FLUORIDE | AstaTech | 375-72-4 | MFCD00007422 | 302.090 | C4F10O2S | 95.000 | FC(F)(F)C(F)(F)C(F)(F)C(F)(F)S(F)(=O)=O | 50g | 392631970
![Medchemexpress LLC Octanoic acid, 8-[(1,1-dimethylethoxy)carbonyl]amino | 30100-16-4 | MFCD00270350 | ≥97.0% | 259.34 g/mol | C13H25NO4 | 25 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000209751.png-250.jpg)
Medchemexpress LLC Octanoic acid, 8-[(1,1-dimethylethoxy)carbonyl]amino | 30100-16-4 | MFCD00270350 | ≥97.0% | 259.34 g/mol | C13H25NO4 | 25 G
N-Boc-8-amino-octanoic acid is a Boc-protected amino acid with an eight-carbon aliphatic spacer and a terminal carboxylic acid. It is used as a flexible linker in PROTAC and peptide synthesis; the carboxylic acid can be coupled to amines to form amide bonds, and the Boc protecting group can be removed under mild acidic conditions to reveal the free amine.
- Boc-protected amino acid suitable for peptide and PROTAC linker synthesis.
- Eight-carbon aliphatic spacer provides flexible linkage.
- Terminal carboxylic acid reactive for amide bond formation.
- Boc group removable under mild acidic conditions.
- Purity ≥97.0% and white to off-white solid appearance.
- Available in multiple package sizes, including 25 G.
Medchemexpress LLC BAY-678 | 675103-36-3 | 99.59% | 400.35 | 50 MG
BAY-678 is an orally bioavailable, highly potent, selective, and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. It is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC). For research use only; not sold to patients.
- Orally bioavailable
- Highly potent and selective inhibitor of human neutrophil elastase (HNE)
- Cell-permeable
- IC50 of 20 nM (HNE)
- Ki value for MNE is 700 nM
- Fourth-generation HNE inhibitor
- More than 2,000-fold selectivity in a panel of 21 serine proteases
- Reveals significant efficacy in preclinical models of ALI and lung emphysema, demonstrating anti-inflammatory and anti-remodeling mode of action
- Shown significant beneficial pulmonary hemodynamic and vascular effects in models of PAH in rats and mice
