Alkyl fluorides
Sigma Aldrich Pentafluoropropionic anhydride
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich Heptafluorobutyric anhydride
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich Heptafluorobutyric acid
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich Perfluorooctanoic Acid
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
TARGETMOL CHEMICALS INC BAY-678 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. BAY-678 is a human neutrophil elastase (HNE; IC50 20 nM) inhibitor with oral bioactivity potency and selectivity.BAY-678 is a chemical probe recommended by the Structural Genomics Consortium (SGC). purity: 98%
TARGETMOL CHEMICALS INC X-376 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. X-376 (Ensartinib) is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration X-396 binds to and inhibits ALK kinase ALK fusion proteins and ALK point mutation variants. Inhibition of ALK leads to the disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. purity: 98%
eMolecules 307-24-4 | Perfluorohexanoic acid | Combi-Blocks, Inc. | MFCD00198040 | 314.054 | C6HF11O2 | 98.000 | OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F | 25g | 586077635
Perfluorohexanoic acid | Combi-Blocks, Inc. | 307-24-4 | MFCD00198040 | 314.054 | C6HF11O2 | 98.000 | OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F | 25g | 586077635
![Medchemexpress LLC Octanoic acid, 8-[(1,1-dimethylethoxy)carbonyl]amino | 30100-16-4 | MFCD00270350 | ≥97.0% | 259.34 g/mol | C13H25NO4 | 25 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000209751.png-250.jpg)
Medchemexpress LLC Octanoic acid, 8-[(1,1-dimethylethoxy)carbonyl]amino | 30100-16-4 | MFCD00270350 | ≥97.0% | 259.34 g/mol | C13H25NO4 | 25 G
N-Boc-8-amino-octanoic acid is a Boc-protected amino acid with an eight-carbon aliphatic spacer and a terminal carboxylic acid. It is used as a flexible linker in PROTAC and peptide synthesis; the carboxylic acid can be coupled to amines to form amide bonds, and the Boc protecting group can be removed under mild acidic conditions to reveal the free amine.
- Boc-protected amino acid suitable for peptide and PROTAC linker synthesis.
- Eight-carbon aliphatic spacer provides flexible linkage.
- Terminal carboxylic acid reactive for amide bond formation.
- Boc group removable under mild acidic conditions.
- Purity ≥97.0% and white to off-white solid appearance.
- Available in multiple package sizes, including 25 G.
Medchemexpress LLC BAY-678 | 675103-36-3 | 99.59% | 400.35 | 50 MG
BAY-678 is an orally bioavailable, highly potent, selective, and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. It is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC). For research use only; not sold to patients.
- Orally bioavailable
- Highly potent and selective inhibitor of human neutrophil elastase (HNE)
- Cell-permeable
- IC50 of 20 nM (HNE)
- Ki value for MNE is 700 nM
- Fourth-generation HNE inhibitor
- More than 2,000-fold selectivity in a panel of 21 serine proteases
- Reveals significant efficacy in preclinical models of ALI and lung emphysema, demonstrating anti-inflammatory and anti-remodeling mode of action
- Shown significant beneficial pulmonary hemodynamic and vascular effects in models of PAH in rats and mice
eMolecules 307-24-4 | Perfluorohexanoic acid | Combi-Blocks, Inc. | MFCD00198040 | 314.054 | C6HF11O2 | 98.000 | OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F | 100g | 837463435
Perfluorohexanoic acid | Combi-Blocks, Inc. | 307-24-4 | MFCD00198040 | 314.054 | C6HF11O2 | 98.000 | OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F | 100g | 837463435
Medchemexpress LLC Perfluoropentanoic acid | 2706-90-3 | 98.0% | 264.05 | 25 G
Perfluoropentanoic acid (PFPeA) is a short-chain perfluorinated compound that serves as an important indicator of perfluorinated compound pollution in ecosystems. It has been observed to affect planktonic microbial communities and show certain toxicity in mice studies.
- Indicator of perfluorinated compound pollution
- Impacts planktonic microbial communities
- Can threaten water quality via microbial metabolism
- In vivo studies suggest potential for liver damage and skin inflammation
Cambridge Isotope Laboratories 2H 2H 3H 3H-Perfluorodecanoic acid (7 3 FTCA) (unlabeled) (mix of isomers) 100 ug/mL in methanol 1 2 mL
2H 2H 3H 3H-Perfluorodecanoic acid (7 3 FTCA) (unlabeled) (mix of isomers) 100 ug/mL in methanol 1 2 mL
Medchemexpress LLC LMP2A (426-434) | 152274-91-4 | 96.1% | 906.16 | 25 MG
LMP2A (426-434) is an HLA-A2-restricted cytotoxic T lymphocyte (CTL) epitope of Epstein-Barr virus (EBV) latent membrane protein 2A (LMP2A). It can trigger an immune response in individuals expressing various HLA-A*02 subtypes and induces a strong IFN-γ secretion response, leading to a high proportion of CD8+ IFN-γ+ T cells. It induces specific CTLs that effectively kill target cells expressing LMP2A.
- Suitable for studying EBV-related malignant tumors, such as Hodgkin's disease and nasopharyngeal carcinoma.
- Induces IFN-γ secreting cells at a frequency of 80.6 SFC/5x10⁴ CD8+ T cells (at 20 μg/mL for 24 h).
- Significantly increases the proportion of CD8+IFN-γ+ cells after two weeks of stimulation (at 20 μg/mL).
- Specific CTLs effectively kill peptide-pulsed T2 cells and 293T-LMP2A cells (at 20 μg/mL for 4 h).